Dr Michal Wlodarski, Principal
FOOD & AGRICULTURE
Next generation plant breeding;
Biological seed treatments;
Nanotechnology-based gene delivery;
Plant microbiome manipulation;
Drone imaging for field biomonitoring; etc.
FAST-MOVING CONSUMER GOODS
Sugar & carbohydrates substitutes;
Smart materials for packaging;
Non-thermal processing methods;
Traceability & shelf monitoring, etc.
Virtual reality for R&D and surgery
3D bioprinting, etc.
Machine learning for drug discovery;
Precision drug delivery and smart release;
Cell & gene therapeutics;
IoT for pharma manufacturing;
Our industries of focus in Life Sciences.
Our most recent projects in Life Sciences.
Our most recent µInsight in Life Sciences.
Innovating Pharmaceutical Manufacturing
The pharmaceutical industry is at a critical point, facing rapidly evolving social, healthcare, technological, and regulatory landscapes, as well as more informed and demanding patient groups. In response to these pressures, leaner drug development pipelines and manufacturing processes need to be developed and implemented, with the goal of increasing product quality, process agility, and operational cost-efficiency.
In the context of chemical manufacturing technologies, there has been little de novo innovation. Instead, most new process solutions either build on existing techniques (e.g. flow chemistry and capsule filling) or repurpose know-how from other disciplines (e.g. 3D printing and hot-melt extrusion). The next generation of pharmaceutical manufacturing systems, however, will be more tightly integrated with digital technologies and process analytical technologies (PATs).
PATs range from quality and risk management tools to process monitoring tools, and are particularly relevant for improving process efficiency, adaptability, robustness, and scalability. PATs accomplish these improvements through integration with innovative manufacturing techniques and technologies, including continuous manufacturing and the expanded use of lab robots. The overwhelming amounts of data generated by PATs will require new cloud-based and intelligent data management systems, such as the Internet-of-Things (IoT) infrastructure, to be properly managed. In addition, the cybersecurity of these systems will need to be ensured, and could rely on innovations such as blockchain technologies to track and validate data generated from production processes.
The synthesis of small molecule active pharmaceutical ingredients (APIs) is usually achieved through flow chemistry. PATs will also be important in these applications, as this method depends on microreactor systems. PATs can help maintain rigorous control of reaction conditions, which is essential when performing unstable reactions or using potentially hazardous compounds.
New techniques used in the final stage of manufacturing or moulding pharmaceutical products—including 3D printing, hot-melt extrusion, injection moulding, and capsule filling—all possess certain benefits and drawbacks, but have the potential to meet the growing need for more personalised, on-demand medicines.